Isaiah Schultz » Entries tagged with "antihistamines"

History of Antihistamine

Antihistamines replace histamine of the two receiver sites where it becomes bound to various vulnerable tissues, thus stopping histamine-triggered reactions under such circumstances as stress, inflammation, and allergy. The antihistamines that were the first to be presented are ones that fix at the so-called H1 receiver sites; they are therefore selected H1-blocking agents and face selectively all the pharmacological properties of histamine except those on stomach secretion. The development of these antihistamines dates from 1937, when French scientists discovered compounds that protected animals against both the deadly effects of histamine and those of deadly shock. The first antihistamines were byproducts of ethylamine; aniline-type mixtures, tested later and found to be more powerful, were too poisonous for clinical use. In 1942, the forerunner of modern antihistamines was discovered; then, mixtures that were … Read entire article »

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